Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.64 |
| ▸ | JAK1 | P23458 | 11/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588639 | 0.91 | JAK1 (0.66) | JAK3JAK1CDK2SYKAURKA | |
| SCHEMBL588761 | 0.84 | PKMYT1 (0.59) | JAK3JAK1CDK2SYKAURKA | |
| SCHEMBL589265 | 0.79 | SYK (0.48) | JAK3JAK1SYKAURKAPDGFRB | |
| SCHEMBL341021 | 0.79 | JAK1 (0.69) | JAK3JAK1SYKJAK2TYK2 | |
| SCHEMBL29609942 | 0.79 | JAK1 (0.69) | JAK3JAK1SYKJAK2TYK2 | |
| SCHEMBL24625492 | 0.79 | EGFR (0.68) | PDGFRBPDGFRAEGFRBRD4 | |
| SCHEMBL29793664 | 0.79 | EGFR (0.68) | PDGFRBPDGFRAEGFRBRD4 | |
| SCHEMBL31299815 | 0.78 | JAK3 (0.45) | JAK3JAK1CDK2CCNA2SYK | |
| SCHEMBL31672493 | 0.76 | PAK1 (0.48) | JAK3JAK1CDK2CCNA2CDK1 | |
| SCHEMBL2873675 | 0.76 | PAK1 (0.48) | JAK3JAK1CDK2CCNA2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311825-A1 | Pyrimidineamines as angiogenesis modulators | GlaxoSmithKline LLC (US) | 2011-04-20 | — | — | EP | claimed |
| US-8114885-B2 | Pazopanib hydrochloride and synthesis, chemical intermediates, and dosage forms thereof; anticancer; colon cancer, breast cancer | GLAXOSMITHKLINE LLC (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2311825-A1 | Pyrimidineamines as angiogenesis modulators | GlaxoSmithKline LLC (US) | 2011-04-20 | — | — | EP | disclosed |