Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.70 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889117 | 0.92 | KDR (0.66) | KDRKITFLT3 | |
| SCHEMBL5888998 | 0.90 | KDR (0.70) | KDRKITFLT3 | |
| SCHEMBL7691786 | 0.85 | KDR (0.76) | KDRKIT | |
| SCHEMBL5889102 | 0.85 | KDR (0.66) | KDRKIT | |
| SCHEMBL7684972 | 0.84 | KDR (0.48) | KDRKITFLT3 | |
| SCHEMBL5889043 | 0.83 | KDR (1.00) | KDRKITFLT3 | |
| SCHEMBL5889166 | 0.81 | KDR (0.83) | KDRKITFLT3 | |
| SCHEMBL5889140 | 0.81 | KDR (0.80) | KDRKITFLT3 | |
| SCHEMBL5889168 | 0.81 | KDR (0.81) | KDRKITFLT3 | |
| SCHEMBL5889005 | 0.79 | KDR (0.66) | KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115597-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20040063720-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063720-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDR 5/4885KIT 957/4885FLT3 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.