Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889186 | 0.85 | KDR (1.00) | KDRCHEK1 | |
| SCHEMBL5889166 | 0.83 | KDR (0.83) | KDRCHEK1KIT | |
| SCHEMBL5889049 | 0.82 | KDR (0.73) | KDRKIT | |
| SCHEMBL5889168 | 0.82 | KDR (0.81) | KDRCHEK1KIT | |
| SCHEMBL5889069 | 0.82 | KDR (1.00) | KDRKIT | |
| SCHEMBL5889039 | 0.81 | KDR (1.00) | KDRCHEK1KIT | |
| SCHEMBL6800930 | 0.81 | KDR (1.00) | KDRCHEK1 | |
| SCHEMBL5889162 | 0.81 | KDR (0.67) | KDRKIT | |
| SCHEMBL7691786 | 0.81 | KDR (0.76) | KDRKIT | |
| SCHEMBL6802538 | 0.81 | KDR (0.76) | KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115597-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2006-10-03 | — | — | US | disclosed |