Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591567 | 0.96 | ADORA2A (0.55) | ADORA2AADORA3ADORA1 | |
| SCHEMBL590738 | 0.91 | ADORA2A (0.60) | ADORA2AADORA3ADORA1 | |
| SCHEMBL5140226 | 0.90 | ADORA2A (0.60) | ADORA2AADORA3ADORA1 | |
| SCHEMBL589537 | 0.90 | ADORA2A (0.60) | ADORA2AADORA3ADORA1 | |
| SCHEMBL3154413 | 0.90 | ADORA2A (0.60) | ADORA2AADORA3ADORA1 | |
| SCHEMBL589013 | 0.90 | ADORA2A (0.55) | ADORA2AADORA3ADORA1 | |
| SCHEMBL590304 | 0.89 | ADORA2A (0.52) | ADORA2AADORA3ADORA1 | |
| SCHEMBL589394 | 0.89 | ADORA2A (0.55) | ADORA2AADORA3ADORA1 | |
| SCHEMBL589538 | 0.88 | ADORA2A (0.61) | ADORA2AADORA3ADORA1 | |
| SCHEMBL3257942 | 0.88 | ADORA2A (0.61) | ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114877-B2 | Antiinflammatory agnets; chronic obstructive pulmonary diseases | NOVARTIS AG (CH) | 2012-02-14 | — | — | US | disclosed |
| EP-2012759-B1 | PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2010-03-10 | — | — | EP | disclosed |