Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.77 |
| ▸ | CSF1R | P07333 | 4/20 | 0.71 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.67 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.60 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.60 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | HCK | P08631 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12776777 | 0.87 | BRAF (0.59) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL5896949 | 0.87 | CSF1R (0.75) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL39874 | 0.85 | KCNQ3 (0.70) | BRAFCSF1RPDGFRBKCNQ3KCNQ2 | |
| SCHEMBL17992413 | 0.83 | BRAF (1.00) | BRAFCSF1RKITKDRLCK | |
| SCHEMBL374728 | 0.83 | LCK (0.65) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL14042163 | 0.83 | BRAF (0.62) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL22145723 | 0.82 | BRAF (0.67) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL19073209 | 0.81 | BRAF (0.73) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL6487127 | 0.81 | BRAF (0.70) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL5897754 | 0.81 | BRAF (1.00) | BRAFCSF1RKITKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |