Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.70 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381456 | 0.91 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL3575929 | 0.87 | CHEK2 (0.76) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3916733 | 0.87 | CHEK2 (0.71) | CHEK2EGLN1 | |
| SCHEMBL3564123 | 0.87 | CHEK2 (0.66) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3573596 | 0.86 | CHEK2 (0.72) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL5177605 | 0.84 | CHEK2 (0.68) | CHEK2KMT2A | |
| SCHEMBL3570845 | 0.83 | CHEK2 (0.72) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL2319097 | 0.82 | SCD (0.54) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3560621 | 0.80 | KDM4E (0.66) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL28930292 | 0.80 | KDM4E (0.68) | CHEK2NR4A2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |