Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 15/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573429 | 0.92 | CHEK2 (0.67) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL1379997 | 0.90 | CHEK2 (0.84) | CHEK2 | |
| SCHEMBL4243591 | 0.86 | CHEK2 (0.63) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3568045 | 0.85 | CHEK2 (0.67) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3564159 | 0.85 | CHEK2 (0.67) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3579641 | 0.84 | CHEK2 (0.69) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3566948 | 0.84 | CHEK2 (0.69) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3565186 | 0.84 | CHEK2 (0.69) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL5898189 | 0.84 | CHEK2 (0.66) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL1383372 | 0.83 | CHEK2 (0.83) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |