Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381233 | 0.92 | CHEK2 (0.86) | CHEK2POLB | |
| SCHEMBL3569023 | 0.85 | CHEK2 (0.72) | CHEK2KMT2AALDH1A1 | |
| SCHEMBL3564516 | 0.84 | CHEK2 (0.71) | CHEK2MEN1MAPTKMT2ALMNA | |
| SCHEMBL5177233 | 0.84 | CHEK2 (0.68) | CHEK2MEN1MAPTKMT2AUSP2 | |
| SCHEMBL5177529 | 0.83 | CHEK2 (0.71) | CHEK2KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL10288218 | 0.79 | POLB (0.63) | CHEK2MEN1MAPTKMT2AUSP2 | |
| SCHEMBL1379810 | 0.78 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL3562464 | 0.75 | CHEK2 (0.67) | CHEK2MAPTKMT2ALMNAPOLB | |
| SCHEMBL28930292 | 0.75 | KDM4E (0.68) | CHEK2KMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL1378643 | 0.75 | CHEK2 (0.85) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |