Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 10/20 | 0.53 |
| ▸ | RAB9A | P51151 | 10/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 5/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565757 | 0.84 | CHEK2 (0.69) | CHEK2NPC1RAB9AGAAMLKL | |
| SCHEMBL3564296 | 0.83 | CHEK2 (0.70) | CHEK2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3565150 | 0.82 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL1381395 | 0.82 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5677793 | 0.80 | CHEK2 (0.62) | CHEK2NPC1RAB9AGAAMLKL | |
| SCHEMBL3559345 | 0.80 | KDM4E (0.69) | CHEK2NPC1RAB9AGAAMLKL | |
| SCHEMBL5177655 | 0.80 | CHEK2 (0.65) | CHEK2 | |
| SCHEMBL3563890 | 0.79 | CHEK2 (0.65) | CHEK2NPC1RAB9AGAAMLKL | |
| SCHEMBL3333987 | 0.77 | NPC1 (0.68) | NPC1RAB9AGAAMLKLSMN1; SMN2 | |
| SCHEMBL29386825 | 0.76 | NPC1 (0.88) | NPC1RAB9AGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |