Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 5/20 | 0.33 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL4828675 | 0.79 | CDK2 (0.44) | CCND1CDK2CDK4CCNA2CCNE1 | |
| Methane SCHEMBL4830609 | 0.77 | CDK2 (0.43) | CCND1CDK2CDK4CCNA2CCNE1 | |
| Methane SCHEMBL4826692 | 0.77 | CDK2 (0.37) | CCND1CDK2CDK4CCNA2CCNE1 | |
| Methane SCHEMBL28575123 | 0.75 | NUAK1 (0.43) | CCND1CDK2CDK4CCNA2CCNE1 | |
| Methane SCHEMBL4833710 | 0.75 | CCND1 (0.45) | CCND1CDK2CDK4CCNA2CCNE1 | |
| Methane SCHEMBL28462333 | 0.72 | CCNE1 (0.31) | CCND1CDK2CCNE1CDK6 | |
| Methane SCHEMBL4830525 | 0.72 | CCND1 (0.44) | CCND1CDK2CDK4CCNA2CCNE1 | |
| SCHEMBL5900479 | 0.72 | CCND1 (0.43) | CCND1CDK2CDK4CCNA2CCNE1 | |
| SCHEMBL5900441 | 0.71 | CCND1 (0.54) | CCND1CDK2CDK4CCNA2CCNE1 | |
| SCHEMBL5900502 | 0.71 | CCND1 (0.45) | CCND1CDK2CDK4CCNA2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | PFIZER INC | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | CDK4, CDK2, CCNA1 | CCND1 9/4885CDK2 2/4885CDK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.