Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.66 |
| ▸ | CCND1 | P24385 | 17/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.66 |
| ▸ | CDK2 | P24941 | 7/20 | 0.66 |
| ▸ | CCND2 | P30279 | 7/20 | 0.59 |
| ▸ | CCND3 | P30281 | 7/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5900761 | 0.88 | CDK4 (0.76) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL5900740 | 0.88 | CDK4 (0.80) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL5900632 | 0.84 | CCND1 (0.55) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL5900912 | 0.81 | CDK4 (0.62) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL5900415 | 0.81 | CCNE1 (0.60) | CDK4CCND1CDK2 | |
| SCHEMBL5900347 | 0.81 | CCND1 (0.47) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL5900546 | 0.81 | CCNE1 (0.75) | CDK4CCND1CDK2CCND3 | |
| SCHEMBL5900564 | 0.81 | CCND1 (0.46) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL13554032 | 0.80 | CDK4 (0.70) | CDK4CCND1CCNA2CDK2CCND2 | |
| SCHEMBL4825451 | 0.80 | CDK4 (0.70) | CDK4CCND1CCNA2CDK2CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | PFIZER INC | 2006-06-29 | — | — | US | claimed |
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | PFIZER INC | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | CDK4, CDK2, CCNA1 | CDK4 1/4885CCND1 9/4885CCNA2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.