Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | AANAT | Q16613 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5903761 | 0.90 | CYP1A2 (0.50) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903760 | 0.87 | HDAC1 (0.66) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5904013 | 0.82 | HDAC1 (0.72) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903823 | 0.78 | HDAC1 (0.72) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903792 | 0.76 | HDAC1 (0.50) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5904004 | 0.73 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903866 | 0.73 | HDAC1 (0.66) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903713 | 0.72 | HDAC1 (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8289901 | 0.72 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903728 | 0.71 | HDAC1 (0.56) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122234-A1 | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors | ARGENTA DISCOVERY LIMITED | 2006-06-08 | — | — | US | claimed |
| US-20060122234-A1 | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors | ARGENTA DISCOVERY LIMITED | 2006-06-08 | — | — | US | disclosed |
| EP-1525199-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | Argenta Discovery Limited (GB) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004013130-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122234-A1 | Substituted thienyl-hydroxamic acids as histone deacetylase inhibitors | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC3 7/4885HDAC4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.