Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5905546 | 0.92 | HRH3 (0.47) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5905509 | 0.92 | HRH3 (0.47) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5284002 | 0.91 | HRH3 (0.48) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5905692 | 0.90 | CHRNA7 (0.43) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5904941 | 0.89 | CHRNA7 (0.48) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5242490 | 0.89 | CHRNA7 (0.48) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5905523 | 0.89 | CHRNA7 (0.43) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5905534 | 0.89 | CHRNA7 (0.47) | HRH3CHRNA7KMT2AMEN1ALDH1A1 | |
| SCHEMBL5904947 | 0.88 | EPHX2 (0.46) | HRH3KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL5905167 | 0.88 | KDM4E (0.44) | HRH3CHRNA7ALDH1A1SLC6A4KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | NEUROGEN CORPORATION | 2006-01-12 | — | — | US | claimed |
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | NEUROGEN CORPORATION | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | MCHR1, MCHR2, PRLHR | HRH3 136/4885CHRNA7 403/4885KMT2A 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.