Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4807197 | 1.00 | BACE1 (1.00) | BACE1NPC1RAB9A | |
| SCHEMBL4809661 | 0.89 | BACE1 (1.00) | BACE1 | |
| SCHEMBL4805928 | 0.88 | BACE1 (1.00) | BACE1 | |
| SCHEMBL4812986 | 0.88 | BACE1 (0.93) | BACE1 | |
| SCHEMBL4814785 | 0.86 | BACE1 (0.82) | BACE1 | |
| SCHEMBL4811549 | 0.86 | BACE1 (0.75) | BACE1NPC1RAB9A | |
| SCHEMBL4811531 | 0.86 | BACE1 (0.75) | BACE1NPC1RAB9A | |
| SCHEMBL4812852 | 0.86 | BACE1 (1.00) | BACE1 | |
| SCHEMBL4806984 | 0.84 | BACE1 (0.75) | BACE1 | |
| SCHEMBL5915918 | 0.82 | BACE1 (0.69) | BACE1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183792-A1 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183792-A1 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators | BACE1, BACE2, PSEN1 | BACE1 1/4885NPC1 130/4885RAB9A 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.