⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592113 | 0.94 | — | — | |
| SCHEMBL591235 | 0.92 | — | — | |
| SCHEMBL592341 | 0.88 | CYP2C19 (0.56) | — | |
| SCHEMBL12812135 | 0.87 | — | — | |
| SCHEMBL12811746 | 0.86 | CYP2C19 (0.61) | — | |
| SCHEMBL592241 | 0.85 | — | — | |
| SCHEMBL592667 | 0.85 | — | — | |
| SCHEMBL592153 | 0.85 | CYP2C19 (0.62) | — | |
| SCHEMBL592240 | 0.83 | — | — | |
| SCHEMBL591324 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114891-B2 | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof | COMENTIS, INC. (US) | 2012-02-14 | — | — | US | claimed |
| EP-2217597-B1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS INC (US) | 2011-03-30 | — | — | EP | claimed |
| US-20090088418-A1 | 4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | COMENTIS, INC. (US) | 2009-04-02 | — | — | US | claimed |
| US-8114891-B2 | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof | COMENTIS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8114891-B2 | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof | COMENTIS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8114891-B2 | 4-substituted quinuclidine derivatives, methods of production, pharmaceutical uses thereof | COMENTIS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2217597-B1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS INC (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-2217597-B1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS INC (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-2217597-A1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS, INC. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009046025-A1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009046025-A1 | QUINUCLIDIN-4-YLMETHYL 1H-INDOLE-3-CARBOXYLATE DERIVATIVES AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | COMENTIS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |
| US-20090088418-A1 | 4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | COMENTIS, INC. (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088418-A1 | 4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | COMENTIS, INC. (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088418-A1 | 4-SUBSTITUTED QUINUCLIDINE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | COMENTIS, INC. (US) | 2009-04-02 | — | — | US | disclosed |