Sugi Predict

Sugi Predict / Compounds / SCHEMBL5936232

SCHEMBL5936232

SCHEMBL5936232

CNC(=O)N[C@H]1CC[C@@H](n2cc(-c3cccc(OCc4ccccc4)c3)c3c(N)ncnc32)CC1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 11/20 0.72
▸ FLT3 P36888 8/20 0.69
▸ INSR P06213 5/20 0.69
▸ LYN P07948 4/20 0.69
▸ LCK P06239 4/20 0.69
▸ KDR P35968 4/20 0.69
▸ ROCK2 O75116 3/20 0.69
▸ FGFR1 P11362 3/20 0.69
▸ FLT4 P35916 3/20 0.69
▸ AURKA O14965 2/20 0.69
▸ CHEK2 O96017 2/20 0.69
▸ CSF1R P07333 2/20 0.69
▸ RPS6KB1 P23443 2/20 0.69
▸ MARK3 P27448 2/20 0.69
▸ CSNK1D P48730 2/20 0.69
▸ BLK P51451 2/20 0.69
▸ NEK2 P51955 2/20 0.69
▸ LIMK1 P53667 2/20 0.69
▸ STK3 Q13188 2/20 0.69
▸ ROCK1 Q13464 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5936230 1.00 IGF1R (0.72) IGF1RFLT3INSRLYNLCK
SCHEMBL5936277 0.92 IGF1R (0.70) IGF1RFLT3INSRLYNLCK
SCHEMBL5936272 0.92 IGF1R (0.70) IGF1RFLT3INSRLYNLCK
SCHEMBL5936295 0.92 IGF1R (0.76) IGF1RFLT3INSRLYNLCK
SCHEMBL5936283 0.92 IGF1R (0.69) IGF1RFLT3INSRLYNLCK
SCHEMBL5936267 0.92 IGF1R (0.71) IGF1RFLT3INSRLYNLCK
SCHEMBL5936286 0.92 IGF1R (0.69) IGF1RFLT3INSRLYNLCK
SCHEMBL5936269 0.92 IGF1R (0.71) IGF1RFLT3INSRLYNLCK
SCHEMBL5936184 0.92 IGF1R (0.71) IGF1RFLT3INSRLYNLCK
SCHEMBL5936186 0.92 IGF1R (0.71) IGF1RFLT3INSRLYNLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100413867-C 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2008-08-27 — — CN claimed
US-20060058324-A1 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives CAPRARO HANS-GEORG 2006-03-16 — — US claimed
CN-1711269-A 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2005-12-21 — — CN claimed
EP-1562947-A1 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES Novartis AG (CH) 2005-08-17 — — EP claimed
WO-2004043962-A1 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES NOVARTIS AG (CH) 2004-05-27 — — WO claimed
CN-100413867-C 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2008-08-27 — — CN disclosed
US-20060058324-A1 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives CAPRARO HANS-GEORG 2006-03-16 — — US disclosed
CN-1711269-A 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives NOVARTIS AG (CH) 2005-12-21 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060058324-A1 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives TYMP, TYMS, APRT IGF1R 3891/4885FLT3 831/4885INSR 2862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.