⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21664662 | 0.85 | — | — | |
| SCHEMBL867084 | 0.83 | — | — | |
| Methoxymethane SCHEMBL10627012 | 0.79 | CHRM2 (0.31) | — | |
| SCHEMBL1792611 | 0.71 | — | — | |
| SCHEMBL5077086 | 0.71 | — | — | |
| SCHEMBL44897 | 0.71 | — | — | |
| SCHEMBL13006245 | 0.69 | — | — | |
| SCHEMBL11542277 | 0.69 | — | — | |
| SCHEMBL5953619 | 0.69 | — | — | |
| SCHEMBL9816172 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137606-B | Short-acting benzodiazepine derivatives, method for the production thereof and use thereof | 四川科伦博泰生物医药股份有限公司 | 2021-01-26 | — | — | CN | claimed |
| CN-106892924-B | Short-acting benzodiazepine derivatives, method for the production thereof and use thereof | 四川科伦博泰生物医药股份有限公司 | 2021-01-08 | — | — | CN | claimed |
| US-20180312511-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3363801-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2018-08-22 | — | — | EP | claimed |
| CN-108137606-B | Short-acting benzodiazepine derivatives, method for the production thereof and use thereof | 四川科伦博泰生物医药股份有限公司 | 2021-01-26 | — | — | CN | disclosed |
| CN-106892924-B | Short-acting benzodiazepine derivatives, method for the production thereof and use thereof | 四川科伦博泰生物医药股份有限公司 | 2021-01-08 | — | — | CN | disclosed |
| US-20180312511-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2018-11-01 | — | — | US | disclosed |
| EP-3363801-A1 | SHORT-ACTING BENZODIAZEPINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2018-08-22 | — | — | EP | disclosed |
| US-9161922-B2 | Amine oxidase inhibitors | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-10-20 | — | — | US | disclosed |
| US-20060100269-A1 | Use of 10-aminoaliphatyl-dibenz[b,f]oxepines for the treatment of degenerative ocular disorders | LAMBROU GEORGE N | 2006-05-11 | — | — | US | disclosed |
| EP-1589963-A1 | USE OF 10-AMINOALIPHATYL-DIBENZ B,F OXEPINES FOR THE TR EATMENT OF DEGENERATIVE OCULAR DISORDERS | Novartis AG (CH) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004066993-A1 | USE OF 10-AMINOALIPHATYL-DIBENZ[B,F]OXEPINES FOR THE TREATMENT OF DEGENERATIVE OCULAR DISORDERS | NOVARTIS AG (CH) | 2004-08-12 | — | — | WO | disclosed |
| WO-2003057204-A2 | MODULATION OF IAMT (PIMT OR PCMT) IN IMMUNE SYSTEM | NORDIC BIOSCIENCE A/S (DK) | 2003-07-17 | — | — | WO | disclosed |
| US-5780501-A | ADMINISTERING TO A MAMMAL | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| US-5780500-A | Anti-neurodegeneratively active 10-aminoaliphatyl-dibenzi b,f! oxepines | NOVARTIS CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| US-5120764-A | Administering penicillamine and allenylamines to inhibit crosslinking of collagen | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0374440-A2 | Inhibitors of lysyl oxidase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0011608-A1 | Novel allenic amine and acid addition salts thereof, a process for their preparation, pharmaceutical preparations comprising them and the use of these compounds in the preparation of pharmaceutical compositions | Astra Läkemedel Aktiebolag (SE) | 1980-05-28 | — | — | EP | disclosed |