Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538725 | 0.99 | HRH3 (0.60) | HRH3KCNH2ADRA1ATDO2 | |
| SCHEMBL2534496 | 0.89 | HRH3 (0.48) | HRH3KCNH2ADRA1A | |
| SCHEMBL2533358 | 0.88 | HRH3 (0.48) | HRH3KCNH2ADRA1A | |
| SCHEMBL2539966 | 0.86 | HRH3 (0.64) | HRH3KCNH2ADRA1ATDO2 | |
| SCHEMBL2115596 | 0.86 | HRH3 (0.53) | HRH3KCNH2ADRA1A | |
| SCHEMBL2114237 | 0.85 | HRH3 (0.53) | HRH3KCNH2ADRA1A | |
| SCHEMBL12226790 | 0.78 | HRH3 (0.58) | HRH3KCNH2 | |
| SCHEMBL2542652 | 0.77 | HRH3 (0.72) | HRH3KCNH2ADRA1A | |
| SCHEMBL2535241 | 0.77 | HRH3 (0.72) | HRH3KCNH2ADRA1A | |
| SCHEMBL2539790 | 0.77 | HRH3 (0.49) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060178375-A1 | Heteroaryloxy nitrogenous saturated heterocyclic derivative | MSD K.K. (JP) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178375-A1 | Heteroaryloxy nitrogenous saturated heterocyclic derivative | HRH3, HRH4, HCRTR2 | HRH3 1/4885KCNH2 1053/4885ADRA1A 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.