Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.80 |
| ▸ | RET | P07949 | 11/20 | 0.80 |
| ▸ | KIF5B | P33176 | 10/20 | 0.80 |
| ▸ | FLT1 | P17948 | 6/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.77 |
| ▸ | EGFR | P00533 | 4/20 | 0.69 |
| ▸ | FLT4 | P35916 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7214437 | 0.98 | KDR (0.77) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5958939 | 0.89 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7215117 | 0.88 | KDR (0.98) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5958928 | 0.87 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7215166 | 0.86 | KDR (0.98) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5958891 | 0.86 | KDR (0.84) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7211029 | 0.85 | KDR (0.83) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL14564694 | 0.83 | EGFR (0.57) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5864525 | 0.82 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL5958924 | 0.81 | KDR (0.83) | KDRRETKIF5BFLT1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| EP-1407261-A4 | IN VIVO BIOREACTORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20050079159-A1 | In vivo bioreactors | MASSACHUSETTS INSTIUTE OF TECHNOLOGY (US) | 2005-04-14 | — | — | US | disclosed |
| EP-1407261-A1 | IN VIVO BIOREACTORS | Massachusetts Institute of Technology (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2002101385-A1 | IN VIVO BIOREACTORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-12-19 | — | — | WO | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |