Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.77 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4339756 | 0.95 | PDE4B (0.72) | PDE4BNR3C1PDE4D | |
| SCHEMBL4338611 | 0.92 | PDE4B (0.79) | PDE4BNR3C1PDE4D | |
| SCHEMBL4332554 | 0.90 | PDE4B (0.83) | PDE4BNR3C1PDE4D | |
| SCHEMBL4337728 | 0.90 | PDE4B (0.83) | PDE4BNR3C1PDE4D | |
| Trifluoroacetic Acid SCHEMBL4335287 | 0.90 | PDE4B (0.70) | PDE4BNR3C1PDE4D | |
| SCHEMBL4335648 | 0.89 | PDE4B (0.84) | PDE4BNR3C1PDE4D | |
| SCHEMBL5962686 | 0.88 | PDE4B (0.80) | PDE4BNR3C1PDE4D | |
| SCHEMBL4335574 | 0.88 | PDE4B (0.79) | PDE4BNR3C1PDE4D | |
| SCHEMBL4332624 | 0.88 | PDE4B (0.81) | PDE4BNR3C1PDE4D | |
| SCHEMBL4332529 | 0.88 | PDE4B (0.81) | PDE4BNR3C1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089375-A1 | Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LIMITED (GB) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089375-A1 | Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors | PDE5A, PDE3B, PDE4A | PDE4B 4/4885NR3C1 16/4885PDE4D 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.