Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339627 | 0.91 | PDE4B (1.00) | PDE4B | |
| SCHEMBL4346136 | 0.88 | PDE4B (0.81) | PDE4B | |
| SCHEMBL2770977 | 0.86 | PDE4B (0.76) | PDE4B | |
| SCHEMBL2771092 | 0.86 | PDE4B (0.76) | PDE4B | |
| SCHEMBL4339788 | 0.86 | PDE4B (0.82) | PDE4B | |
| SCHEMBL6471819 | 0.85 | PDE4B (0.78) | PDE4B | |
| SCHEMBL4336108 | 0.85 | PDE4B (0.77) | PDE4B | |
| SCHEMBL4332802 | 0.85 | PDE4B (0.80) | PDE4B | |
| SCHEMBL4336374 | 0.85 | PDE4B (0.98) | PDE4B | |
| SCHEMBL4350690 | 0.85 | PDE4B (0.83) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089375-A1 | Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LIMITED (GB) | 2006-04-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089375-A1 | Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors | PDE5A, PDE3B, PDE4A | PDE4B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.