Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 13/20 | 0.54 |
| ▸ | FLT4 | P35916 | 13/20 | 0.54 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966458 | 0.88 | FLT1 (0.61) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966431 | 0.83 | FLT1 (0.66) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966437 | 0.81 | FLT1 (0.54) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5958964 | 0.81 | FLT1 (0.54) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966440 | 0.79 | FLT1 (0.54) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966688 | 0.78 | FLT1 (0.58) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966644 | 0.78 | FLT1 (0.67) | FLT1FLT4KDR | |
| SCHEMBL5966459 | 0.77 | FLT1 (0.60) | FLT1FLT4KDRGPR27ALDH1A1 | |
| SCHEMBL5958965 | 0.74 | FLT1 (0.84) | FLT1FLT4KDRGPR27EGFR | |
| SCHEMBL5966492 | 0.74 | FLT1 (0.55) | FLT1FLT4KDRGPR27SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |