Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31487879 | 0.87 | FLT1 (0.49) | FLT1FLT4KDRAVPR2GPR27 | |
| SCHEMBL5966451 | 0.86 | FLT1 (0.65) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5958921 | 0.79 | FLT1 (0.77) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966432 | 0.78 | FLT1 (0.58) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5959045 | 0.75 | FLT1 (0.79) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966434 | 0.75 | FLT1 (0.55) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966492 | 0.75 | FLT1 (0.55) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5966465 | 0.75 | FLT1 (0.58) | FLT1FLT4KDRAVPR2GPR27 | |
| SCHEMBL5958978 | 0.74 | FLT1 (0.77) | FLT1FLT4KDRCES2AVPR2 | |
| SCHEMBL5959029 | 0.74 | FLT1 (1.00) | FLT1FLT4KDRAVPR2GPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442030-B1 | THIOPENE- AMD THIAZOLESULFONAMIDES AS ANTINEOPLASTIC AGENTS | LILLY CO ELI (US) | 2006-08-30 | — | — | EP | disclosed |