Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC27A1 | Q6PCB7 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200066 | 0.86 | MEN1 (0.68) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL4199207 | 0.86 | TSHR (0.70) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL4206699 | 0.85 | TSHR (0.69) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL6061181 | 0.83 | MEN1 (0.64) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL4204241 | 0.82 | TSHR (1.00) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL5793722 | 0.78 | MEN1 (0.60) | MEN1KMT2ATSHRLMNAHPGD | |
| SCHEMBL4199802 | 0.78 | TSHR (0.75) | MEN1KMT2ATSHRLMNAGAA | |
| SCHEMBL4203551 | 0.73 | TSHR (0.70) | TSHRLMNAHPGDNPSR1GAA | |
| SCHEMBL4211130 | 0.72 | MEN1 (0.78) | MEN1KMT2ATSHRLMNANPSR1 | |
| SCHEMBL4208252 | 0.72 | TSHR (0.70) | MEN1KMT2ATSHRLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615667-A2 | COMBINATIONS OF AN 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST | NOVO NORDISK A/S (DK) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089415-A2 | COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | WO | disclosed |