⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987900 | 0.86 | — | — | |
| SCHEMBL3908644 | 0.84 | — | — | |
| SCHEMBL7206576 | 0.78 | — | — | |
| SCHEMBL291961 | 0.75 | — | — | |
| SCHEMBL6397732 | 0.75 | — | — | |
| SCHEMBL8425592 | 0.71 | — | — | |
| SCHEMBL18741509 | 0.69 | — | — | |
| SCHEMBL8164590 | 0.68 | — | — | |
| SCHEMBL1569788 | 0.66 | KDM4E (0.42) | — | |
| SCHEMBL2302995 | 0.65 | DPP7 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140121192-A1 | METHODS OF GENERATING BETA-LACTAMASE RESISTANT CARBAPENEM COMPOUNDS | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-01 | — | — | US | claimed |
| EP-1245564-B1 | BENZAMIDINE DERIVATIVES | SANKYO CO (JP) | 2006-04-05 | — | — | EP | claimed |
| US-20040248981-A1 | Benzamidine derivatives | SANKYO COMPANY, LIMITED (JP) | 2004-12-09 | — | — | US | claimed |
| US-20040010009-A1 | Benzamidine derivatives | SANKYO COMPANY, LIMITED (JP) | 2004-01-15 | — | — | US | claimed |
| US-6555556-B1 | N-(4-(1-acetimidoylpiperidin-4-yl)oxyphenyl)-N-((E)-3-(3 -amidinophenyl)-2-methyl-2-propenyl)sulfamoylacetic acid dihydrochloride for example; factor Xa inhibitors | SANKYO COMPANY, LIMITED (JP) | 2003-04-29 | — | — | US | claimed |
| EP-1245564-A1 | BENZAMIDINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-10-02 | — | — | EP | claimed |
| US-5856556-A | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY, LIMITED (JP) | 1999-01-05 | — | — | US | claimed |
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | claimed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0102239-B1 | AZETIDINONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS INTERMEDIATES IN THE PREPARATION OF CARBAPENEM ANTIBIOTICS | SANKYO COMPANY LIMITED (JP) | 1987-10-14 | — | — | EP | claimed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | claimed |
| CN-86107574-A | Compositions containing penem or carbapenem antibiotics and their use | — | 1987-05-20 | — | — | CN | claimed |
| EP-0102239-A1 | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY LIMITED (JP) | 1984-03-07 | — | — | EP | claimed |
| WO-2014070774-A1 | METHODS OF GENERATING BETA-LACTAMASE RESISTANT CARBAPENEM COMPOUNDS | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-08 | — | — | WO | disclosed |
| US-20140121192-A1 | METHODS OF GENERATING BETA-LACTAMASE RESISTANT CARBAPENEM COMPOUNDS | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-01 | — | — | US | disclosed |
| CN-101821259-B | Substituted (oxazolidinon-5-yl-methyl) -2-thiophene-carboxamides and use thereof in field of blood coagulation | BAYER HEALTHCARE AG | 2013-10-30 | — | — | CN | disclosed |
| EP-0102239-B1 | AZETIDINONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS INTERMEDIATES IN THE PREPARATION OF CARBAPENEM ANTIBIOTICS | SANKYO COMPANY LIMITED (JP) | 1987-10-14 | — | — | EP | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |
| CN-86107574-A | Compositions containing penem or carbapenem antibiotics and their use | — | 1987-05-20 | — | — | CN | disclosed |
| EP-0102239-A1 | Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics | SANKYO COMPANY LIMITED (JP) | 1984-03-07 | — | — | EP | disclosed |