Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 9/20 | 0.56 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743647 | 0.80 | PDE7A (0.73) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1645800 | 0.79 | MAPT (0.60) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1340757 | 0.79 | PDE7A (0.55) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1644247 | 0.77 | PDE7A (0.56) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1341060 | 0.77 | PDE7A (0.55) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1644221 | 0.76 | SLC6A4 (0.69) | PDE7ALMNATDP1SLC6A2SLC6A4 | |
| SCHEMBL1644242 | 0.76 | PDE7A (0.49) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL6741226 | 0.76 | PDE7A (0.67) | PDE7ATXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL1644238 | 0.75 | SLC6A4 (0.76) | PDE7AMAPTLMNAPOLBL3MBTL1 | |
| SCHEMBL1645187 | 0.75 | SLC6A4 (0.64) | PDE7AMAPTLMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519917-A4 | CARBON-11 AND FLUORINE-18 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR THE BRAIN SEROTONIN TRANSPORTERS | UNIV COLUMBIA (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-1519917-A2 | CARBON-11 AND FLUORINE-18 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR THE BRAIN SEROTONIN TRANSPORTERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2005-04-06 | — | — | EP | disclosed |
| WO-2003096978-A2 | CARBON-11 AND FLUORINE-18 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR THE BRAIN SEROTONIN TRANSPORTERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2003-11-27 | — | — | WO | disclosed |