Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 11/20 | 0.57 |
| ▸ | HINT1 | P49773 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5982600 | 1.00 | KRAS (0.57) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL24359099 | 0.98 | KRAS (0.55) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL17417839 | 0.92 | KRAS (0.53) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL17417840 | 0.92 | KRAS (0.53) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL16002733 | 0.92 | KRAS (0.53) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL7614827 | 0.85 | HPGD (0.59) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL7614834 | 0.85 | HPGD (0.59) | KRASHINT1HPGDTAS1R3TAS1R1 | |
| SCHEMBL27659 | 0.85 | ADORA2A (0.58) | HINT1HPGDTAS1R3TAS1R1NT5E | |
| SCHEMBL27658 | 0.85 | ADORA2A (0.58) | HINT1HPGDTAS1R3TAS1R1NT5E | |
| SCHEMBL26198 | 0.84 | ADORA2A (0.58) | HINT1HPGDTAS1R3TAS1R1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037646-B1 | Amine-derivatized nucleosides and oligonucleosides | ISIS PHARMACEUTICALS, INC. (US) | 2006-05-02 | — | — | US | disclosed |
| EP-0728139-B1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS INC (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0728139-A1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995006659-A1 | AMINE-DERIVATIZED NUCLEOSIDES AND OLIGONUCLEOSIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-03-09 | — | — | WO | disclosed |