Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 4/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5983241 | 1.00 | TLR2 (0.54) | TLR2MDM2NOD1TNFMDM4 | |
| SCHEMBL1740478 | 0.91 | MDM2 (0.54) | TLR2MDM2MDM4TP53 | |
| SCHEMBL14920476 | 0.86 | MDM2 (0.55) | TLR2MDM2MDM4TP53 | |
| SCHEMBL29503829 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL7420121 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL1044856 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL30645689 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL1000115 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL29382791 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 | |
| SCHEMBL29367120 | 0.86 | TLR2 (0.62) | TLR2MDM2TNFMDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656390-A2 | COMPOSITIONS OF LIPOPEPTIDE ANTIBIOTIC DERIVATIVES AND METHODS OF USE THEREOF | MIGENIX INC. (CA) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005000878-A2 | COMPOSITIONS OF LIPOPEPTIDE ANTIBIOTIC DERIVATIVES AND METHODS OF USE THEREOF | MIGENIX INC. (CA) | 2005-01-06 | — | — | WO | disclosed |