Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480760 | 0.88 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CJAK1 | |
| SCHEMBL3471184 | 0.86 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5056744 | 0.85 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4CJAK1 | |
| Hydrochloric Acid SCHEMBL3470610 | 0.85 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6386857 | 0.83 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL5482662 | 0.83 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL5484477 | 0.82 | PDE4D (0.44) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL2350503 | 0.81 | PDE4D (0.44) | PDE4DPDE4BPDE4APDE4CKMT2A | |
| SCHEMBL3470159 | 0.80 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL6384297 | 0.80 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725534-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087745-A1 | NOVEL AMIDO-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-22 | — | — | WO | disclosed |