Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990630 | 0.92 | PDGFRB (0.52) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5990240 | 0.91 | PDGFRB (0.51) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5380602 | 0.86 | PDGFRB (0.69) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5999741 | 0.86 | PDGFRB (0.69) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5988621 | 0.84 | KDR (0.52) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6389339 | 0.83 | PDGFRB (0.74) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL6391776 | 0.81 | RET (0.49) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5991104 | 0.80 | ABL1 (0.46) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5987815 | 0.79 | ABL1 (0.41) | PDGFRBFGFR1ABL1RETFLT3 | |
| SCHEMBL5988465 | 0.79 | ABL1 (0.45) | PDGFRBFGFR1ABL1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849641-B1 | Azaindole tyrosine kinase inhibitors | SUGEN, INC. (US) | 2005-02-01 | — | — | US | claimed |
| US-6987113-B2 | Tyrosine kinase inhibitors | SUGEN, INC. (US) | 2006-01-17 | — | — | US | disclosed |