Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | CDK8 | P49336 | 3/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275274 | 0.88 | RAF1 (0.40) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL6689156 | 0.82 | ABL1 (0.60) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL6234408 | 0.81 | SRC (0.60) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL7602984 | 0.75 | MAPK9 (0.68) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL5987723 | 0.72 | MAPK14 (0.36) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL5988576 | 0.72 | MAPK14 (0.53) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL4086687 | 0.71 | MAPK14 (0.53) | RAF1ABL1LYNSRCMAPK9 | |
| SCHEMBL6270980 | 0.71 | MAPK14 (0.35) | RAF1MAPK14TNFMAPK12BRAF | |
| SCHEMBL5998813 | 0.71 | MAPK14 (0.34) | RAF1MAPK14TNFMAPK12BRAF | |
| SCHEMBL5988417 | 0.71 | MAPK14 (0.34) | RAF1MAPK14TNFMAPK12BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658060-A2 | METHODS OF TREATING COPD AND PULMONARY HYPERTENSION | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-05-24 | — | — | EP | claimed |
| WO-2005018624-A2 | METHODS OF TREATING COPD AND PULMONARY HYPERTENSION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | claimed |