Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.65 |
| ▸ | PPARA | Q07869 | 13/20 | 0.65 |
| ▸ | PPARD | Q03181 | 11/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989690 | 0.90 | PPARG (0.76) | PPARGPPARAPPARD | |
| SCHEMBL5988805 | 0.89 | PPARG (0.67) | PPARGPPARAPPARDABCB11CYP1A2 | |
| SCHEMBL5989481 | 0.88 | PPARG (0.69) | PPARGPPARAPPARDABCB11CYP1A2 | |
| SCHEMBL5990132 | 0.86 | PPARG (0.71) | PPARGPPARAPPARD | |
| SCHEMBL5991338 | 0.85 | PPARG (0.57) | PPARGPPARAPPARDABCB11CYP1A2 | |
| SCHEMBL5990218 | 0.82 | PPARG (0.73) | PPARGPPARAPPARDTSHRMAPK1 | |
| SCHEMBL5989893 | 0.81 | PPARG (0.72) | PPARGPPARAPPARD | |
| SCHEMBL5402182 | 0.79 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL5989776 | 0.78 | PPARG (0.48) | PPARGPPARAPPARDTSHRMAPK1 | |
| SCHEMBL5990393 | 0.78 | PPARG (0.78) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |