Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.60 |
| ▸ | CCR3 | P51677 | 20/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.60 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929508 | 0.97 | HRH1 (0.63) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL5992722 | 0.87 | HRH1 (0.51) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1929040 | 0.86 | HRH1 (0.67) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1929936 | 0.84 | HRH1 (0.75) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1930117 | 0.82 | HRH1 (0.70) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1928207 | 0.80 | HRH1 (0.65) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1929042 | 0.77 | HRH1 (0.63) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL2914439 | 0.77 | HRH1 (0.74) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL1929387 | 0.76 | HRH1 (0.62) | HRH1CCR3KCNH2CCR1 | |
| SCHEMBL18844310 | 0.75 | HRH1 (1.00) | HRH1CCR3KCNH2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713772-A1 | NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005073192-A1 | NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) | ASTRAZENECA AB (SE) | 2005-08-11 | — | — | WO | disclosed |