Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.63 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14778357 | 0.84 | MEN1 (0.66) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL14788068 | 0.84 | MEN1 (0.66) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL14778359 | 0.84 | MEN1 (0.66) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL5991093 | 0.80 | POLB (0.57) | BRAFGSK3AGSK3BMEN1KMT2A | |
| SCHEMBL5147278 | 0.80 | BRAF (0.66) | BRAFGSK3AGSK3BMEN1KMT2A | |
| SCHEMBL25633689 | 0.79 | MEN1 (0.61) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL1066159 | 0.78 | DUSP3 (0.74) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL1066160 | 0.78 | DUSP3 (0.74) | BRAFMEN1KMT2ADUSP3POLB | |
| SCHEMBL5145115 | 0.77 | BRAF (0.68) | BRAFGSK3AGSK3BMEN1KMT2A | |
| SCHEMBL5145120 | 0.77 | BRAF (0.68) | BRAFGSK3AGSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065139-A2 | ENTPD5 INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-05-18 | — | — | WO | disclosed |