Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL597215 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRHCRTR1HCRTR2GRM2 | |
| SCHEMBL1908573 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRHCRTR1HCRTR2GRM2 | |
| SCHEMBL1908540 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRHCRTR1HCRTR2GRM2 | |
| SCHEMBL9929765 | 0.88 | CYP3A4 (0.36) | SMN1; SMN2TSHRMMEACEACE2 | |
| SCHEMBL18175828 | 0.88 | CYP3A4 (0.36) | SMN1; SMN2TSHRMMEACEACE2 | |
| SCHEMBL9974772 | 0.88 | CYP3A4 (0.36) | SMN1; SMN2TSHRMMEACEACE2 | |
| SCHEMBL17965498 | 0.87 | TSHR (0.41) | SMN1; SMN2TSHRHCRTR1HCRTR2GRM2 | |
| SCHEMBL8198647 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRHCRTR1HCRTR2GRM2 | |
| SCHEMBL598389 | 0.86 | KLK7 (0.45) | — | |
| SCHEMBL598255 | 0.86 | KLK7 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115016-B2 | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid | NOVARTIS AG (CH) | 2012-02-14 | — | — | US | disclosed |
| EP-2121578-A2 | NEW PROCESS | Novartis AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008083967-A2 | PROCESS FOR PREPARING 5-BIPHENYL-4-AMINO-2-METHYL PENTANOIC ACID | NOVARTIS AG (CH) | 2008-07-17 | — | — | WO | disclosed |