Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.64 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999693 | 0.88 | HDAC3 (0.71) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL1366507 | 0.87 | HDAC1 (0.67) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL27350259 | 0.84 | MEN1 (0.83) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL2942358 | 0.84 | MEN1 (0.96) | MEN1KMT2AGAAEPHX2FAAH | |
| SCHEMBL1185619 | 0.84 | GAA (0.66) | MEN1KMT2AGAAEPHX2LMNA | |
| SCHEMBL19334536 | 0.82 | MEN1 (0.78) | MEN1KMT2AHDAC1HDAC8HDAC3 | |
| SCHEMBL15800860 | 0.81 | TRPV1 (0.73) | KMT2AHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL14254953 | 0.81 | MEN1 (0.89) | MEN1KMT2AGAAEPHX2FAAH | |
| SCHEMBL27909119 | 0.81 | MEN1 (0.89) | MEN1KMT2AGAAEPHX2FAAH | |
| SCHEMBL5998899 | 0.81 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006028972-A2 | MERCAPTOAMIDES AS HISTONE DEACETYLASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | AHMED SALEH | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | HDAC1, HDAC11, HDAC2 | MEN1 1917/4885KMT2A 23/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.