Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038058 | 0.85 | HDAC3 (0.51) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5999381 | 0.78 | HDAC3 (0.69) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL8272561 | 0.77 | HDAC3 (0.79) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5998809 | 0.76 | HDAC8 (0.77) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5999674 | 0.76 | HDAC8 (0.77) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL6000067 | 0.76 | HDAC3 (0.77) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL8272148 | 0.76 | HDAC8 (0.77) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL5998508 | 0.76 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL10113629 | 0.76 | HDAC6 (0.47) | HDAC3HDAC1HDAC6KEAP1NFE2L2 | |
| SCHEMBL10113898 | 0.76 | HDAC6 (0.47) | HDAC3HDAC1HDAC6KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006028972-A2 | MERCAPTOAMIDES AS HISTONE DEACETYLASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | AHMED SALEH | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | HDAC1, HDAC11, HDAC2 | HDAC3 7/4885HDAC1 1/4885HDAC4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.