Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785818 | 0.93 | LCK (0.84) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL773819 | 0.92 | LCK (1.00) | LCKSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5516409 | 0.90 | LCK (0.87) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL774092 | 0.89 | LCK (0.79) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL774903 | 0.89 | LCK (0.79) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL774606 | 0.88 | LCK (0.77) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL774166 | 0.88 | LCK (0.80) | LCKSMN1; SMN2KDM4E | |
| SCHEMBL771411 | 0.88 | LCK (0.80) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL774218 | 0.87 | LCK (0.76) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL769189 | 0.86 | LCK (0.74) | LCKSMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153856-B2 | Cyclic protein tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-26 | — | — | US | disclosed |