Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cpg-52852. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 known ✓ | Q9NYK1 | 19/20 | 0.73 |
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.59 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744632 | 0.90 | TLR7 (0.81) | TLR7TLR8NUDT1 | |
| SCHEMBL29421427 | 0.89 | TLR7 (0.73) | TLR7TLR8NUDT1 | |
| SCHEMBL29421426 | 0.89 | TLR7 (0.73) | TLR7TLR8NUDT1 | |
| SCHEMBL1616712 | 0.89 | TLR7 (0.73) | TLR7TLR8NUDT1 | |
| Water SCHEMBL4531043 | 0.88 | TLR7 (0.72) | TLR7TLR8NUDT1 | |
| SCHEMBL3968461 | 0.87 | TLR7 (0.76) | TLR7TLR8NUDT1 | |
| Cpg-52852 SCHEMBL483385 | 0.85 | TLR7 (1.00) | TLR7TLR8 | |
| Cpg-52852 SCHEMBL29371102 | 0.85 | TLR7 (1.00) | TLR7TLR8 | |
| SCHEMBL6000001 | 0.85 | TLR7 (0.63) | TLR7TLR8NUDT1 | |
| SCHEMBL728616 | 0.84 | TLR7 (0.69) | TLR7TLR8NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8961477-B2 | Delivery of immune response modifier compounds | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-20060195067-A1 | Delivery of immune response modifier compounds | 3M INNOVATIVE PROPERTIES COMPANY | 2006-08-31 | — | — | US | disclosed |