Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 4/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | GIPR | P48546 | 2/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.31 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000748 | 0.91 | PTPN1 (0.42) | PTPN1PTPN2PPARDPPARAEPHA2 | |
| SCHEMBL6000922 | 0.90 | PTPN1 (0.41) | PTPN1PTPN2ADRB3PPARDPPARA | |
| SCHEMBL6000501 | 0.89 | PTPN1 (0.42) | PTPN1PTPN2PPARDPPARAEPHA2 | |
| SCHEMBL6000910 | 0.89 | PTPN1 (0.40) | PTPN1PTPN2PPARDPPARAEPHA2 | |
| SCHEMBL6000472 | 0.82 | PTPN1 (0.41) | PTPN1PTPN2PPARDPPARAGCGR | |
| SCHEMBL5999470 | 0.81 | PTPN1 (0.49) | PTPN1PTPN2PPARDPPARAALOX5 | |
| SCHEMBL6000953 | 0.80 | PTPN1 (0.39) | PTPN1PTPN2PPARDPPARAALOX5 | |
| SCHEMBL5999963 | 0.79 | PTPN1 (0.45) | PTPN1PTPN2PPARDPPARAALOX5 | |
| SCHEMBL5999169 | 0.79 | PTPN1 (0.47) | PTPN1PTPN2PPARDPPARAALOX5 | |
| SCHEMBL6000167 | 0.79 | PTPN1 (0.49) | PTPN1PTPN2PPARDPPARAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | claimed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | claimed |
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | disclosed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | PTPN11, PTPN1, PTPN3 | PTPN1 2/4885PTPN2 11/4885ADRB3 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.