Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.46 |
| ▸ | RAF1 | P04049 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47765 | 0.90 | SLC34A2 (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL5998771 | 0.90 | BRAF (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL19596314 | 0.90 | BRAF (0.47) | BRAFRAF1HTR2AKCNH2TRPV4 | |
| SCHEMBL6002496 | 0.89 | BRAF (0.47) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL15432658 | 0.88 | BRAF (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL5998372 | 0.86 | BRAF (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL46989 | 0.84 | SLC34A2 (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL5998740 | 0.84 | SLC34A2 (0.46) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL46683 | 0.83 | SLC34A2 (0.45) | BRAFRAF1HTR2AKCNH2SCD | |
| SCHEMBL6001897 | 0.83 | BRAF (0.43) | BRAFRAF1HTR2AKCNH2SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |