Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.66 |
| ▸ | MMP13 | P45452 | 11/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000985 | 0.93 | PTPN2 (0.69) | PTPN2PTPN1MMP13MMP2RAB9A | |
| SCHEMBL6000992 | 0.88 | PTPN2 (0.68) | PTPN2PTPN1MMP13MMP2PSMB5 | |
| SCHEMBL6000764 | 0.87 | PTPN2 (0.66) | PTPN2PTPN1MMP13MMP2RAB9A | |
| SCHEMBL6000626 | 0.87 | PTPN2 (0.66) | PTPN2PTPN1MMP13MMP2PSMB5 | |
| SCHEMBL6001057 | 0.84 | PTPN2 (0.64) | PTPN2PTPN1MMP13MMP2MMP1 | |
| SCHEMBL5999110 | 0.84 | PTPN2 (0.76) | PTPN2PTPN1MMP13MMP2MMP1 | |
| SCHEMBL6001017 | 0.84 | PTPN2 (0.76) | PTPN2PTPN1MMP13MMP2MMP1 | |
| SCHEMBL6000765 | 0.83 | PTPN2 (0.64) | PTPN2PTPN1MMP13MMP2RAB9A | |
| SCHEMBL6000062 | 0.83 | PTPN2 (0.76) | PTPN2PTPN1MMP13MMP2MMP1 | |
| SCHEMBL6000857 | 0.82 | PTPN2 (0.71) | PTPN2PTPN1MMP13MMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | claimed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | claimed |
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | disclosed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | PTPN11, PTPN1, PTPN3 | PTPN2 11/4885PTPN1 2/4885MMP13 2340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.