SCHEMBL6000902

SCHEMBL6000902

CCCCCCC([O])c1ccccn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 3/20 0.46
KCNH2 Q12809 3/20 0.46
CYP2D6 P10635 2/20 0.44
KCNE1 P15382 1/20 0.44
CYP1A2 P05177 3/20 0.42
ALDH1A1 P00352 1/20 0.42
TSHR P16473 1/20 0.41
LMNA P02545 3/20 0.41
KDM4E B2RXH2 2/20 0.41
ALOX12 P18054 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
HTT P42858 1/20 0.41
NPC1 O15118 1/20 0.41
HSP90AA1 P07900 1/20 0.41
RAB9A P51151 1/20 0.41
CHRM2 P08172 3/20 0.40
SLC6A2 P23975 3/20 0.40
SLC6A4 P31645 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12488384 0.86 KCNA5 (0.51) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL21405673 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL29145046 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL28347623 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL28260638 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL28130837 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL28669183 0.83 KCNA5 (0.46) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL20746760 0.83 TSHR (0.51) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL21138628 0.83 TSHR (0.51) KCNA5KCNH2CYP2D6KCNE1CYP1A2
SCHEMBL22374013 0.83 TSHR (0.51) KCNA5KCNH2CYP2D6KCNE1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1678185-A1 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-07-12 EP disclosed
WO-2005042542-A1 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-05-12 WO disclosed