Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092867 | 0.85 | MAPT (0.44) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2094912 | 0.71 | HAO1 (0.47) | KDM4EKCNH2MEN1KMT2APOLB | |
| SCHEMBL12885024 | 0.69 | KDM4E (0.69) | KDM4EGPR84KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL13261015 | 0.69 | KDM4E (0.64) | KDM4EGPR84KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7236230 | 0.67 | KDM4E (0.56) | KDM4EGPR84KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7237460 | 0.67 | KDM4E (0.61) | KDM4EGPR84KCNH2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6250500 | 0.67 | MEN1 (0.43) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL17626133 | 0.66 | EIF4E (0.43) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2095437 | 0.66 | S1PR1 (0.35) | HDAC6 | |
| SCHEMBL3298738 | 0.66 | KDM4E (0.54) | KDM4EGPR84KCNH2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |