Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | GCGR | P47871 | 2/20 | 0.30 |
| ▸ | GIPR | P48546 | 2/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5999167 | 0.87 | PTPN1 (0.54) | PTPN1PTPN2MMP1MMP13S1PR1 | |
| SCHEMBL6000783 | 0.85 | PTPN2 (0.75) | PTPN1PTPN2MMP1MMP13MMP2 | |
| Hydrochloric Acid SCHEMBL6000203 | 0.85 | PTPN1 (0.54) | PTPN1PTPN2MMP1MMP13S1PR1 | |
| Hydrochloric Acid SCHEMBL5999848 | 0.84 | PTPN1 (0.53) | PTPN1PTPN2MMP1MMP13S1PR1 | |
| SCHEMBL6000973 | 0.84 | PTPN1 (0.49) | PTPN1PTPN2MMP1MMP13ALDH1A1 | |
| SCHEMBL6000618 | 0.83 | PTPN1 (0.51) | PTPN1PTPN2MMP1MMP13RAB9A | |
| SCHEMBL5999987 | 0.83 | PTPN1 (0.52) | PTPN1PTPN2MMP1MMP13S1PR1 | |
| SCHEMBL5999977 | 0.83 | PTPN2 (0.51) | PTPN1PTPN2ALDH1A1RAB9A | |
| SCHEMBL6000635 | 0.83 | PTPN1 (0.49) | PTPN1PTPN2MMP1MMP13L3MBTL1 | |
| SCHEMBL6000600 | 0.83 | PTPN2 (0.50) | PTPN1PTPN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | claimed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | claimed |
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | JAPAN TOBACCO INC. (JP) | 2006-06-08 | — | — | US | disclosed |
| EP-1553091-A1 | HETEROAROMATIC PENTACYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122181-A1 | Heteroaromatic pentacyclic compound and medicinal use thereof | PTPN11, PTPN1, PTPN3 | PTPN1 2/4885PTPN2 11/4885MMP1 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.