Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47756 | 0.99 | SLC34A2 (0.44) | SLC34A2OPRK1KCNH2OPRM1OPRD1 | |
| SCHEMBL19596069 | 0.90 | SLC34A2 (0.41) | SLC34A2FFAR4CYSLTR2CYSLTR1CYP4F2 | |
| SCHEMBL15444467 | 0.86 | MEN1 (0.41) | SLC34A2 | |
| SCHEMBL15432931 | 0.86 | MEN1 (0.41) | SLC34A2 | |
| SCHEMBL19596014 | 0.86 | SLC34A2 (0.38) | SLC34A2OPRK1KCNH2OPRM1F2 | |
| SCHEMBL15432965 | 0.85 | MEN1 (0.41) | SLC34A2 | |
| SCHEMBL18471366 | 0.85 | MEN1 (0.41) | SLC34A2 | |
| SCHEMBL19596051 | 0.84 | SLC34A2 (0.44) | SLC34A2 | |
| SCHEMBL19595763 | 0.82 | SLC34A2 (0.62) | SLC34A2EGFRTOP2A | |
| SCHEMBL19595744 | 0.82 | SLC34A2 (0.62) | SLC34A2EGFRTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |