Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd7009. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd7009 SCHEMBL31478886 | 1.00 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| Azd7009 SCHEMBL2966851 | 1.00 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5374500 | 0.89 | KCNH2 (0.70) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1619314 | 0.87 | KCNH2 (0.72) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3605800 | 0.87 | KCNH2 (0.72) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2954489 | 0.87 | KCNH2 (0.51) | KCNH2CA12CA1CA2CA9 | |
| SCHEMBL13701327 | 0.87 | KCNH2 (0.67) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2964384 | 0.86 | KCNH2 (0.56) | KCNH2MEN1CA12CA1CA2 | |
| SCHEMBL2959969 | 0.84 | KCNH2 (0.61) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3129914 | 0.83 | KCNH2 (0.54) | KCNH2MEN1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137772-A1 | NEW PHYSICAL FORM OF N,N´- DISUBSTITUTED OXABISPIDINES | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |