Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727008 | 0.90 | IDO1 (0.50) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL2095031 | 0.84 | IDO1 (0.45) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL6001300 | 0.83 | IDO1 (0.44) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL2096583 | 0.81 | IDO1 (0.45) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL7504635 | 0.79 | IDO1 (0.48) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL3161448 | 0.78 | IDO1 (0.61) | IDO1MAOBMAOASLC6A2SLC6A4 | |
| SCHEMBL2094372 | 0.77 | IDO1 (0.53) | IDO1SCN8AMAOBMAOASLC6A2 | |
| SCHEMBL838892 | 0.75 | IDO1 (0.52) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL12016034 | 0.75 | IDO1 (0.49) | IDO1HDAC1HDAC8GAADAO | |
| SCHEMBL17329111 | 0.74 | IDO1 (0.59) | IDO1HDAC1HDAC8DAOMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |