Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 5/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005363 | 0.99 | CHEK2 (0.42) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6003394 | 0.94 | CHEK2 (0.43) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6003300 | 0.94 | CHEK2 (0.43) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6005446 | 0.92 | CHEK2 (0.44) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6004724 | 0.91 | CHEK2 (0.43) | CHEK2SSTR2AURKBKDM2BESR1 | |
| SCHEMBL6003282 | 0.91 | CHEK2 (0.43) | CHEK2LTA4HAURKBESR1ESR2 | |
| SCHEMBL6005515 | 0.91 | CHEK2 (0.42) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6003362 | 0.90 | CHEK2 (0.43) | CHEK2ESR1ESR2 | |
| SCHEMBL6004667 | 0.90 | CHEK2 (0.41) | CHEK2LTA4HSSTR2AURKBKDM2B | |
| SCHEMBL6003358 | 0.89 | CHEK2 (0.43) | CHEK2LTA4HSSTR2AURKBKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709021-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073204-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2005-08-11 | — | — | WO | disclosed |