Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5981063 | 0.91 | GSTP1 (0.62) | GSTP1AKR1C3AKR1C2HSD17B1HSD17B2 | |
| SCHEMBL6068558 | 0.86 | CYP2C19 (0.55) | AMY1ACYP1A2CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL18963363 | 0.85 | GSTP1 (0.56) | GSTP1AKR1C3AKR1C2HSD17B1HSD17B2 | |
| SCHEMBL227029 | 0.84 | CYP11B1 (0.55) | GSTP1AKR1C3AKR1C2HSD17B1HSD17B2 | |
| SCHEMBL30979884 | 0.82 | APP (0.51) | AMY1ACYP1A2CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL15588476 | 0.82 | APP (0.51) | AMY1ACYP1A2CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL10014739 | 0.81 | AKR1C3 (0.58) | AKR1C3AKR1C2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL225282 | 0.81 | CYP11B1 (0.58) | GSTP1AKR1C3AKR1C2HSD17B1HSD17B2 | |
| SCHEMBL7695294 | 0.80 | CYP1A2 (0.60) | GSTP1HSD17B1HSD17B2CYP1A2TRPA1 | |
| SCHEMBL30979865 | 0.79 | APP (0.46) | AMY1ACYP2C19CYP1A1CYP1B1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709021-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073204-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS | ELI LILLY AND COMPANY (US) | 2005-08-11 | — | — | WO | disclosed |